About Paul

Designer who researches. Scientist who codes. Engineer who ships.

Paul Mangiamele
Computer ScientistHCI ResearcherBench ScientistComputational BiologistProduct LeadDesignerEngineer

I kept crossing boundaries because the interesting problems live between them. I make AI products for people who work in complex domains: AI-driven drug discovery, clinical trials, autonomous vehicles. Curing cancer. Saving babies.

I have a PhD in Human-Computer Interaction, a decade in genomics and proteomics, and 18+ years shipping production code. That combination means I can sit with a drug discovery scientist, understand their workflow, design the interface, and build the system behind it. I set product roadmaps, run research studies, write production code in React and Python, evaluate foundation models, and ship. My prototypes are production-ready, not mockups, which is why my designs ship 85% faster than typical design-to-engineering handoffs.

The through-line across all of it is a question I've been chasing since grad school: why are experts skeptical of computational tools and AI, and what does it take to earn their trust? I've pursued it across four years pioneering agentic AI for drug discovery and autonomous vehicles at AWS, a decade shipping CE-IVD certified clinical decision support at Roche for physicians making life-or-death treatment decisions, and a PhD that gave me the research vocabulary for what I'd been observing all along. The hardest problem in AI isn't making it powerful. It's making it trustworthy—building systems where users understand what the AI is doing, can intervene when needed, and don't lose the parts of their work that make it meaningful.

Outside of work, I'm usually building something; AI tools, self-built solar arrays, Powerwalls, an electric '62 Vespa I converted myself, and a house I built from the ground up. But probably fixing something on that house.

Professional journey

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AWS
2025 - Present

Amazon Web Services (AWS)

Health AI, Applied AI

AWS
2022 - 2025

Amazon Web Services (AWS)

Product and Design Lead, Automotive

2015 - 2022

Roche/Genentech

Principal UX Designer

First Product hire and grew the team. Early employee of RSS (Roche Sequencing Solutions)

2014 - 2016

UX Bio (GeneLinea)

Founder

Deeply passionate on area, but too early in the space.

2014 - 2015

FDB, Workiva, & Others

Startups & Post-Doc Research

Made the decision to go industry after trying both

2012 - 2014

Iowa State University

Head of Bioinformatics & Computational Biology

2008 - 2014

Iowa State University

PhD, Human-Computer Interaction

Focus on Computational Biology

2003 - 2007

Iowa State University

BS, Computer Science & Philosophy

Focus on Machine Learning and Computational Vision