ai-native builder · researcher · scientist · designer

PaulMangiamele, PhD

Based in San Francisco. Head of Research and Design across AWS Applied AI’s Health and Life Sciences portfolio, building GenAI tools that put drug discovery, protein design, and clinical workflows directly in scientists’ hands. PhD in Human-Computer Interaction, production engineering experience, and 18+ years taking products from research to launch — bridging cutting-edge AI and human needs.

Currently building

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Deterministic agents for science

agents · determinism · science

Control flow fixed in code as DAGs — every step grounded in evidence before acting.

Amazon Bio Discovery

aws · genai · biology

GenAI discovery workbench for bench scientists — no code required, used by thousands.

Make It Go

kids · claude · game

A no-reading coding game for ages 3–7 — a Claude partner decides when they're ready.

PG&E Energy MCP

mcp · energy · powerwall

21 MCP tools that answer real questions about your bill, solar, and battery — and act on them.