ai-native builder · researcher · scientist · designer

PaulMangiamele, PhD

Based in San Francisco. I lead research and design for the products and AI experiences that help early-stage biotechs discover medicines faster, as Senior Director, Product Design in Lilly Catalyze360. I came to Lilly from AWS, where I led design across the life sciences portfolio. PhD in Human-Computer Interaction, production engineering experience, and 18+ years taking products from research to launch — bridging cutting-edge AI and human needs.

At a glance

All projects →

Deterministic agents for science

agents · determinism · science

Control flow fixed in code as DAGs — every step grounded in evidence before acting.

Amazon Bio Discovery↗

aws · agentic · biology

shipped

Agentic discovery workbench for bench scientists — no code required, used by thousands.

Make It Go

kids · claude · game

A no-reading coding game for ages 3–7 — a Claude partner decides when they're ready.

PG&E Energy MCP

mcp · energy · powerwall

21 MCP tools that answer real questions about your bill, solar, and battery — and act on them.