ai-native builder · researcher · scientist · designer
PaulMangiamele, PhD
Currently: Head of Research & Design, Life Sciences · AWS Applied AI
Based in San Francisco. Head of Research and Design across AWS Applied AI’s Life Sciences portfolio, building agentic tools that put drug discovery, protein design, and clinical workflows directly in scientists’ hands. PhD in Human-Computer Interaction, production engineering experience, and 18+ years taking products from research to launch — bridging cutting-edge AI and human needs.
Currently building
All projects →Deterministic agents for science
agents · determinism · science
Control flow fixed in code as DAGs — every step grounded in evidence before acting.
Amazon Bio Discovery↗
aws · genai · biology
Agentic discovery workbench for bench scientists — no code required, used by thousands.
Make It Go
kids · claude · game
A no-reading coding game for ages 3–7 — a Claude partner decides when they're ready.
PG&E Energy MCP
mcp · energy · powerwall
21 MCP tools that answer real questions about your bill, solar, and battery — and act on them.
